1

Database preparation of patients with primary immunodeficiency referred to Isfahan medical center

2

In vivo, Gene delivery to CD34 cells at mice

3

In vitro, Gene delivery to CD34 cells at mice

4

Providing a Biobank from patients with inflammatory bowel diseases which suspected to immunodeficiency diseases referred to Isfahan digestive diseases research centers 2014-2015

5

Providing and setup a demographic data-bank,clinical and drowing pedigree from patients with inflammatory bowel diseases and suspected to immunodeficiency diseases referred to Isfahan medical,universitese and research centers in 2014

6

Evaluation of B cell maturation antigen (BCMA) expression on B cells as well as counting peripheral blood plasma blast cells in patients with CVID in compare with healthy controls

7

Investigation of mutation existence in GATA2 gene prevalent exones in patients with suspected mendelian susceptibility to mycobacterial diseasereferred to health and educational centers of Isfahan University of medical sciences

8

IFNGR1 gene mutations in patients with suspected mendelian susceptibility to mycobacterial disease referred to health and educational centers, Isfahan University of medical sciences

9

Determination of mutation in 1, 2 and 3 axons of LI 10 AR gene and 1 to 7 exons of LI 10RB in patients with Inflammatory bowel disease suspected with primary immunodeficiency referred to Research Centers Immunodeficiency and Subspecialty Clinic Gastroenterology of Isfahan University of Medical Sciences

10

Comparative evaluation of cytomegalovirus avidity and Quantiferon in pregnant women with early onset pre-eclampsia and women with normal pregnancy

11

IL-12RB gene mutations in patients with suspected mendelian susceptibility to mycobacterial disease referred to health and educational centers of Isfahan University of medical sciences

12

Screening of patients with suspected mendelian Susceptibility to Mycobacterial Disease for IL-12p40 deficiency

13

Investigation of mutation existence in exons of IL 12B gene in patients with suspected mendelian susceptibility to mycobacterial disease referred to health and educational centers of Isfahan University of medical sciences

14

The assessment serology  of Coxiella burnetii in butchers in Isfahan in 2015

15

Determination of polymorphism in axon4 of LI 10 AR gene in healthy volunteers in Isfahan in 2016-2017

16

Determination of polymorphism in axon7 of LI 10 AR gene in healthy volunteers in Isfahan in 2016-2017

17

Screening and detection of immune deficiency for cell surface expression of IFN-γR1 in patients suspected to Mendelian susceptibility to mycobacterial

18

Evaluation of allelic frequencies of SNP in NFKBIA gene in colorectal cancer patients and their normal controls in Isfahan.

19

Assessment of mutation existence in selected axon)ex6( of GATA2 genein patients suspected to Mendelian susceptibility to mycobacterial infection that referred to the health and educational centers of Isfahan University of medical sciences

20

Comparative evaluation of cell-mediatetd immunity to cytomegalovirus, in pregnant women with early onset preeclampsia and women with normal pregnancy

21

Evaluation and comparison of natural killer cell cytotoxic activity in Hepatitis B patients, susceptible families to hepatitis B and normal population.

22

Utilization of Recombinant Allergens from American Cockroach (Periplaneta Americana) for Component Resolved Diagnosis

23

Evalutaion of mRNA expression and Protein level in non-bruton gammaglobulinemia by real time PCR and western bloting

24

Assessment of TIM-3) T cell immunoglobulin and Mucin-3) expression on PBMC of Hepatitis B patients and normal population, and evaluation of its correlation with cytotoxicity of natural killer cells

25

Providing a Biobank from patients with Mendelian susceptibility to mycobacterial diseases referred to Isfahan digestive diseases research centers in 2017-2018

26

Database and bio bank preparation of patients with autoinflammatory syndrome referred to Isfahan medical center

27

Stablish demographic data bank of neutropenic patient and genetically evaluation and proteome analysis of patient with severe congenital neutropenia to complete Next generation sequencing analysis panel

28

Confirmation of Whole Exome Sequencing Results and Segregation Analysis by Sanger Sequencing in a Family with Primary Immunodeficieny Diseases in Isfahan

29

Evaluation of the relationship between disease severity score on CT scan and nasopharyngeal viral shedding in 30 patients admitted with COVID-19 in Amin Hospital of Isfahan in 1399

30

Comparison of the Effect of Lymphotherapy and Prednisolone Therapy on the Change in the Population of Myeloid Suppressor Cells (MDSCs) and Stimulation of the Granulocytic Subpopulation of These Cells in Women with Recurrent Spontaneous Abortion (RSA)

31

 Comparison of the Effect of Lymphotherapy and Prednisolone Therapy on Subpopulation and Phenotype Change of Natural Killer Cells (NK) and NKT Cells in Women with Recurrent Spontaneous Abortion (RSA)

32

Comparison of RDW level in patients with Covid-19, Cleared from ward, from ICU and Died in Al-Zahra Hospital

33

Identification of Inborn Errors of Immunity in patients with severe and critical COVID-19 through Whole Exome Sequencing (WES) by next generation sequencing method

34

Evaluation of possible genetic susceptibility mutations to severe COVID-19 in exon 8 of IRF7 gene in Iranian families with severe COVID-19

35

Evaluation of the expression and function of Natural killer cells in familial unexplained RPL (recurrent pregnancy loss) and control subjects in Isfahan

36

Evaluation of possible predisposing mutations of COVID-19 in exon 2 of the IRF7 gene in families with Severe COVID-19

37

Evaluation of Immune checkpoint genes (TIM-3,PD1)  in the severity of covid-19 disease in three groups patients in Isfahan city

38

 Evaluation of rs6598045 variant on IFITM3 gene in patients of severe and critical COVID-19 through Sequencing by Sanger sequencing method

39

Confirmation of Novel Whole Exome Sequencing Results and Segregation Analysis by Sanger Sequencing in Two Families with Diseases of immune dysregulation in Isfahan

40

Confirmation of Novel Whole Exome Sequencing Results and Segregation Analysis by Sanger Sequencing in Two Families with Diseases of immune dysregulation in Isfahan

41

Segregation analysis and confirmation of whole exome sequencing novel reported variants by performing Sanger sequencing in families with inborn errors of immunity  

42

Evaluation of pathogen variants predisposing to SARS-CoV 2 in exons 2 and 8 of the IRF7 gene in patients with severe and critical COVID-19 after full COVID-19 vaccination

43

Evaluation of pathogen variants predisposing to SARS-CoV 2 in exon 3 of the IRF7 gene in patients with severe and critical COVID-19 after full COVID-19 vaccination

44

Investigation of the presence of polymorphism in 3 of the TLR7 gene in patients with severe and critical COVID-19 through Sequencing by Sanger sequencing method

45

Biobank preparation for patients with severe COVID-19 and critical COVID-19 suspected to primary immunodeficiency in Isfahan population

46

Evaluation of prophylactic effects of colchicine in preventing COVID-19 in patients with behcet’s disease

47

Evaluation of the protein patterns in the plasma of patients suspected to common variable immunodeficiency (CVID)

48

Evaluation of rs6598045 variant on IFITM3 gene in patients of severe and critical COVID-19 through Sequencing by Sanger sequencing method

49

The evaluation of Demographic, immunologic and genetic in suspected CVID patients between 1377-1400

50

Evaluation of the protein patterns in the plasma of patients suspected to Hyper-immunoglobulin M (HIGM)

51

Evaluation of SAMD9 protein expression in a patient with immunodeficiency containing novel mutant variant of SAMD9 gene

52

Eenvestigation of protein expression  of plasma in patients  with common variable immunodeficiency (CVID) confirming with NGS

53

Evaluation of possible pathogenic variants of the CYP21A2 gene in families with unexplained recurrent pregnancy loss in Isfahan between the years 1398-1402

54

Study of the possibility of primary immunodeficiency in patients with multiple sclerosis (MS) receiving Rituximab

55

Evaluation of rs34481144 and rs12252 variants on IFITM3 gene in patients of severe and critical COVID-19 through Sequencing by Sanger sequencing method

56

Examination of SAMD9 gene expression in patients with infertility/recurrent pregnancy loss (RPL) with suspected immunodeficiency

57

Examination of EGR1 gene expression at the mRNA level in patients with infertility /recurrent pregnancy loss (RPL) with suspected immunodeficiency