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Research projects

Research projects

۱) Genetic evaluation of patients with suspected Mendelian susceptibility to mycobacterial infections , referred to Isfahan University of medical sciences health and educational centers or clinics.‎ 1-1) Genetic evaluation of GATA2 gene prevalent exones in patients with suspected mendelian susceptibility to mycobacterial disease.‎ 1-2) Genetic evaluation of IL 12B gene exones in patients with suspected mendelian susceptibility to mycobacterial disease.‎ 1-3) Screening of IL-12p40 production by immune cells in patients with suspected Mendelian Susceptibility to Mycobacterial Disease in culture after stimulation with Bacillus Calmette–Guerin 1-4) Evaluation of mutations in IL12RB1 domain in patients with mendelian susceptibility to mycobacterial disease .‎ 1-5)Genetic evaluation of IfY Receptor gene prevalent exones in patients with suspected mendelian susceptibility to mycobacterial disease.‎ 2) Providing and setup a demographic , clinical , pedigree and biobank of patients with PID , Isfahan university of Medical Sciences 3) Providing and setup a demographic , clinical data, pedigree and biobank of patients with inflammatory bowel diseases and suspected to immunodeficiency diseases referred to Gastroenterology clinics and research centers , Isfahan university of Medical Sciences 2014-2015 4) Genetic evaluation of patients with CVID in relation to their clinical presentations 4-1)Clinical Features of Immunological Dysregulation (autoimmunity, allergy , malignancy ) in Common Variable Immunodeficiency 4-2) Evaluation of B cell maturation antigen (BCMA) expression on B cells as well as counting peripheral blood plasma blast cells in patients with CVID in compare with healthy controls 4-3) Evaluation of the T helper 17 cell specific genes and ILC in CVID 5) Comparative evaluation of cytomegalovirus serology ,IgG IgM and CMV avidity , in pregnant women with early onset preeclampsia and women with normal pregnancy 6) Comparative evaluation of cell-mediatetd immunity to cytomegalovirus in pregnant women with early onset preeclampsia and women with normal pregnancy.‎ 7)) Natural killer cell Ig-like receptor (KIR) genotypes in patients with chronic hepatitis B, families with hepatitis B and healthy subjects 8) T lymphocyte Proliferation against Candida antigen by CFSC method in women with recurrent vulvovaginal Candidiosis and normal controls.‎ 9)Genetic and functional evaluation of Th17 pathway in patients with susceptibility to candidiasis 10) Genetic Evaluation of IL12RB1 in Patients with chronic and retractable Leishmaniasis 11)In vivo, Gene delivery to CD34 cells at mice
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